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Alstonia Scholaris (L) R.Br 

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Common name : Scholar Tree, Dita bark, Devil tree, chatiun
  • Vernacular Names
    1. Assamese : Mahaneem. Maha-neem 2. Bengali : Neem 3. English : Indian Lilac, Margosa, Margosa tree, Neem,Neem tree 4. Gujarati : Limba 5. Hindi : Neem 6. Irula : Veeppa, maram 7. Kannada : Bevu/ Kirubevu, Turakabevu 8. Malayalam : Ariyaveppu, Ayurveppu, Kaippanveppu , Nimbam, Vembu, Veppu 9. Marathi : Nimbay 10. Tamil : Sengumaru, Vembu, Veppa, Veppai 11. Telugu : Vepa Source : FRLHT’s ENVIS
  • Botanical Description
    Azadirachta indica is a tropical evergreen of the MELIACEAE family that grows up to 25 m high. It has rough dark brown bark with wide longitudinal fissures separated by flat ridges. The leaves are compound, imparipinnate, each comprising 5-15 leaflets that are arranged in alternate pairs with terminal leaflets. The compound leaves are themselves alternating with one another. The thin, lanceolate leaflets measure about 6 cm long and 2 cm broad. It bears many flowered panicles, mostly in the leaf-axils. The sepals are ovate and about 1 cm long with sweet scented white oblanceolate petals. It produces yellow drupes that are ellipsoid and glabrous, 12-20 cm long. Source : Medicinal plants of the world: chemical constituents, traditional and modem medicinal uses by Ivan Ross (Volume 2 )
  • Conservation Status
    Least concern source : IUCN
  • Medicinal uses
    Hot water extract of the bark is taken orally by the adult female as a tonic and emmenagogue. The hot water extract of the dried fixed oil is taken orally as an emmenagogue. Anthraquinone fraction of the dried flower, fruit and leaf is taken orally for leprosy. Hot water extract of the flower and leaf is taken orally as an antihistorical remedy, and is used externally to treat wounds. The dried flowers are taken orally for diabetes. Hot water extract of the dried fruit is used for piles and externally for skin diseases and ulcers. Hot water extract of the entire plant is taken orally as an anthelmintic, an insecticide and a purgative. Juices of the bark of Andrographis paniculate, Azadirachta indica and Tinospora cordifolia are taken orally as a treatment for filariasis. Hot water extract of the bark is taken with water, orally before breakfast, for leprosy. The extract is also taken for fever and diabetes, and as a tonic, refrigerant, anthelmintic and antiperiodic. The fresh fruit is used externally for leprosy. Fruit, leaf and root, ground and mixed with dried ginger and "trifala", a preparation consisting of the powdered fruit of Terminalia bellerica (Gaertn.) Roxb., T. Chebula Retz, and Emblica officinalis Gaertn., is taken orally with lukewarm water to treat common fevers. Leaf juice is administered by intravenous infusion for chronic skin diseases, and is taken orally as an anthelmintic. Source : Medicinal Plants of the World
S.No
Phytochemical name
Phytochemical ID
2D structures
3D structures
part
1
Alstonidine
CID_12305773
stem bark
2
O-methylmacralstonine
n.a
stem bark
3
macralstonine O-acetylmacralstonine
n.a
stem bark
4
alstonine
CID_441979
stem bark
5
ditamine
N.A
stem bark
6
echicaoutchin
N.A
stem bark
7
corialstonidine
CID_101656124
stem bark
8
corialstonine
CID_6443266
stem bark
9
villalstonine
CID_5476353
stem bark
10
pleiocarpamine
CID_5385014
stem bark
11
macrocarpamine
CID_5472477
stem bark
12
alpha-amyrin linoleate
CID_9987141
stem bark
13
lupeol palmitate
CID_161739
stem bark
14
lupeol linoleate
CID_53787397
stem bark
15
12-methoxyechitamidine
CID_21586664
stem bark
16
5-epinareline ethyl ether
n.a
stem bark
17
Nareline methyl ether
CID_101712320
stem bark
18
scholaricine
CID_50900051
stem bark
19
Picrinine
CID_46229104
stem bark
20
19-hyroxytubotaiwine
N.A
stem bark
21
Na-metylburnamine
N.A
stem bark
22
19-epischolarine
N.A
stem bark
23
angustilobine
CID_13891905
stem bark
24
20(S)-tubotaiwine
CID_13783720
stem bark
25
6,7-seco-angustilobine
CID_13891912
stem bark
26
5-methoxystrictamine,
CID_102004590
stem bark
27
picralinal
CID_46229103
stem bark
28
5-methoxyaspidophylline
N.A
stem bark
29
stigmasterol
CID_5280794
Root
30
α-sitosterol
CID_9548595
Root
31
chlorogenic acid
CID_1794427
Seed
32
reserpine
CID_5770
Seed
33
7-megastigmene-3, 6, 9-triol
N.A
Leaves
34
megastigmane-3β, 4α, 9-triol
N.A
Leaves
35
2, 3-secofernane
N.A
leaves

The IC50 values of hexane extract (A. scholaris), isopropanol extract (A. venenata), and quercetin were 90.5 ± 6.2, 7.5 ± 1.2, and 31.5 ± 2.5 µg/mL, respectively.

Source : KANASE et al.,2018

Disclaimer: The main motive behind the construction of this database is to compile information from the scientific literature on Indian medicinal plants to aid ongoing research efforts in the field of computational drug discovery.The curated data should be used only for research purposes and not for any self-diagnosis or any medical treatment.

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