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AZADIRACHTA INDICA

Common name : Neem 

Source: freepik.com 

Azadirachta indica distribution
  • Vernacular Names
    1. Assamese : Mahaneem. Maha-neem 2. Bengali : Neem 3. English : Indian Lilac, Margosa, Margosa tree, Neem,Neem tree 4. Gujarati : Limba 5. Hindi : Neem 6. Irula : Veeppa, maram 7. Kannada : Bevu/ Kirubevu, Turakabevu 8. Malayalam : Ariyaveppu, Ayurveppu, Kaippanveppu , Nimbam, Vembu, Veppu 9. Marathi : Nimbay 10. Tamil : Sengumaru, Vembu, Veppa, Veppai 11. Telugu : Vepa Source : FRLHT’s ENVIS
  • Botanical Description
    Azadirachta indica is a tropical evergreen of the MELIACEAE family that grows up to 25 m high. It has rough dark brown bark with wide longitudinal fissures separated by flat ridges. The leaves are compound, imparipinnate, each comprising 5-15 leaflets that are arranged in alternate pairs with terminal leaflets. The compound leaves are themselves alternating with one another. The thin, lanceolate leaflets measure about 6 cm long and 2 cm broad. It bears many flowered panicles, mostly in the leaf-axils. The sepals are ovate and about 1 cm long with sweet scented white oblanceolate petals. It produces yellow drupes that are ellipsoid and glabrous, 12-20 cm long. Source : Medicinal plants of the world: chemical constituents, traditional and modem medicinal uses by Ivan Ross (Volume 2 )
  • Conservation Status
    Least concern source : IUCN
  • Medicinal uses
    Hot water extract of the bark is taken orally by the adult female as a tonic and emmenagogue. The hot water extract of the dried fixed oil is taken orally as an emmenagogue. Anthraquinone fraction of the dried flower, fruit and leaf is taken orally for leprosy. Hot water extract of the flower and leaf is taken orally as an antihistorical remedy, and is used externally to treat wounds. The dried flowers are taken orally for diabetes. Hot water extract of the dried fruit is used for piles and externally for skin diseases and ulcers. Hot water extract of the entire plant is taken orally as an anthelmintic, an insecticide and a purgative. Juices of the bark of Andrographis paniculate, Azadirachta indica and Tinospora cordifolia are taken orally as a treatment for filariasis. Hot water extract of the bark is taken with water, orally before breakfast, for leprosy. The extract is also taken for fever and diabetes, and as a tonic, refrigerant, anthelmintic and antiperiodic. The fresh fruit is used externally for leprosy. Fruit, leaf and root, ground and mixed with dried ginger and "trifala", a preparation consisting of the powdered fruit of Terminalia bellerica (Gaertn.) Roxb., T. Chebula Retz, and Emblica officinalis Gaertn., is taken orally with lukewarm water to treat common fevers. Leaf juice is administered by intravenous infusion for chronic skin diseases, and is taken orally as an anthelmintic. Source : Medicinal Plants of the World
S.No
Phytochemical name
phytochemical ID
synonyms
Part
2D structure
3D structure
Medicinal properties
1
Azadirachtin
CID_5281303
Azadirachtin A
Seed
Antiecdysic Antitrypanosomic
2
Azadirachtol
CID_23256847
NA
Fruit
NA
3
Azadiradione
CID_12308714
NA
seed
Antifeedant Antimalarial
4
Behenic acid
CID__8215
Docosanoic acid 1-Docosanoic acid
Fruit
NA
5
Beta-sistosterol
CID_222284
Sitosterol Cupreol Azuprostat
Leaf ,flower
Androgenic Anorexic Antiandrogenic Antibacterial Anticancer Antiestrogenic Antileukemic Antilymphomic Antiophidic Antipyretic Antitumor Antiviral Cancer preventive
6
Catechin
CID_9064
Cianidanol Catechuic acid
NA
NA
7
Desacetylnimbin
10505484
Deacetylnimbin 6-Deacetylnimbin 6-Desacetylnimbin
Stem, Bark
NA
8
Desacetylsalannin
NA
NA
NA
NA
9
Epicatechin
CID_72276
L-Epicatechin
NA
NA
10
Gedunin
CID_ 12004512
Gedunine
Seed
Antimalarial Cytotoxic
11
Hyperoside
CID_5281643
Hyperin Hyperosid Quercetin 3-galactoside
Leaf
Antiaging Antibacterial Antihepatotoxic Antioxidant Antiviral Cancer preventive Diuretic
12
Isomeldenin
CID_76316558
NA
NA
NA
13
Isonimbinolide
CID_14136864
NIMBIN PP
Stem, bark
NA
14
Kaempferol
CID_5280863
Kempferol Robigenin Kaempherol
Flower
Antiaggregant Antiallergic Antibacterial Anticancer Antifertility Anti-inflammatory Antileukemic Antioxidant Antiseptic Antispasmodic Antitumor Cytotoxic Diuretic
15
Kaempferol-3-O-beta-D-glucoside
CID_25203515
kaempferol-3-O-D-glucoside
NA
NA
16
Kaempferol-3-O-rutinoside
CID_5318767
Nicotiflorin, Nictoflorin, NICOTIFLOROSIDE
NA
NA
17
Khivorin
CID_21596331
NA
NA
NA
18
Kulactone
CID_15560423
NA
NA
NA
19
Limocinin
CID_14845550
NA
NA
NA
20
Margocinin
CID_101529197
NA
NA
NA
21
Margolone
CID_189728
12-methyl-7-oxopodocarpa-8,11,13-triene-13-carboxylic acid
NA
NA
22
Myricetin
CID_5281672
Cannabiscetin Myricetol Myricitin
Flower
Antiallergenic Antibacterial Antifeedant Anti gastric Anti-inflammatory Antioxidant Antiseptic Antiviral Apoptotic Cancer preventive Vasodilator
23
Nimbandiol
CID_157277
NA
Stem ,Leaf
Antimalarial Antiplasmodial
24
Nimbidiol
CID_11334829
NA
NA
NA
25
Nimbin
CID_108058
NA
Stem ,Bark
Antiallergic Antihistaminic Antimalarial Fungicide Pesticide Spermicide
26
Nimbinin
CID_49863985
Epoxyazadiradione
Stem ,Bark
Antimalarial Antiplasmodial Antiulcer Cytotoxic Pesticide Antiarthritic
27
Nimbinone
CID_189403
12-hydroxy-13-methylpodocarpa-8,11,13-triene-3,7-dione
stem,bark
NA
28
Nimbiol
CID_11119228
Nimbial
bark
NA
29
Nimbolide
CID_12313376
NA
leaf
Antimalarial Antiplasmodial Cytotoxic
30
Nimocinol
CID_178770
NIMONOL
Fruit
Anti malarial Anti plasmodial
31
Nimosone
CID_189660
12,13-dimethoxypodocarpa-8(14),9(11),12-triene-3,7-dione
NA
NA
32
Ohchinin Acetate
CID_52952322
NA
NA
NA
33
Ohchinolide B
CID_6440507
NA
NA
NA
34
Quercetin
CID_5280343
Meletin Sophoretin Xanthaurine
Leaf ,Flower
Antiaging Antiallergic Anti anaphylactic Antiarthritic Antibacterial Antidepressant Antimalarial Antioxidant Antitumor Antiviral Vasodilator
35
Quercetin-3-O-Beta-D-glucoside
CID_25203368
Isoquercitrin quercetin-3-glucoside
NA
NA
36
Rutin
CID_5280805
rutoside Phytomelin Quercetin 3-rutinoside
Leaf
Antiallergic Anti apoplectic Antibacterial Anticancer Anticonvulsant Antidiabetic Antihemorrhodial Anihepatotoxic Antihistaminic Antioxidant Antiprotozoal Antispasmodic Antisunburn Antiulcer Cancer preventive Immunomodulator Vasodilator Vasopressor
37
Salannin
CID_6437066
NA
Seed
Antimalarial Pesticide Insecticide
38
Salannol
CID_157144
NA
NA
NA
39
Scopoletin
CID_5280460
Gelseminic acid
Plant
Analgesic Antibacterial Antioxidant Antiseptic Antitumor
40
Sugiol
CID_94162
NA
bark
NA
41
Vilasinin
CID_185729
NA
leaf
NA
42
Zafaral
CID_101355583
NA
NA
NA

In DPPH free radical scavenging test, IC50 value of the crude extract was found to be fairly significant (13.81±0.06 µg/ml) while compared with that of the reference standards, ascorbic acid and BHA (2.12±0.02 and 4.87±0.05 µg/ml, respectively).

Source for phytochemicals : Duke's and pubchem 

Disclaimer: The main motive behind the construction of this database is to compile information from the scientific literature on Indian medicinal plants to aid ongoing research efforts in the field of computational drug discovery.The curated data should be used only for research purposes and not for any self-diagnosis or any medical treatment.

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