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 Calotropis gigantea 

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Common name : mudar,crown flower
  • Vernacular Names
    1. Assamese : Mahaneem. Maha-neem 2. Bengali : Neem 3. English : Indian Lilac, Margosa, Margosa tree, Neem,Neem tree 4. Gujarati : Limba 5. Hindi : Neem 6. Irula : Veeppa, maram 7. Kannada : Bevu/ Kirubevu, Turakabevu 8. Malayalam : Ariyaveppu, Ayurveppu, Kaippanveppu , Nimbam, Vembu, Veppu 9. Marathi : Nimbay 10. Tamil : Sengumaru, Vembu, Veppa, Veppai 11. Telugu : Vepa Source : FRLHT’s ENVIS
  • Botanical Description
    Azadirachta indica is a tropical evergreen of the MELIACEAE family that grows up to 25 m high. It has rough dark brown bark with wide longitudinal fissures separated by flat ridges. The leaves are compound, imparipinnate, each comprising 5-15 leaflets that are arranged in alternate pairs with terminal leaflets. The compound leaves are themselves alternating with one another. The thin, lanceolate leaflets measure about 6 cm long and 2 cm broad. It bears many flowered panicles, mostly in the leaf-axils. The sepals are ovate and about 1 cm long with sweet scented white oblanceolate petals. It produces yellow drupes that are ellipsoid and glabrous, 12-20 cm long. Source : Medicinal plants of the world: chemical constituents, traditional and modem medicinal uses by Ivan Ross (Volume 2 )
  • Conservation Status
    Least concern source : IUCN
  • Medicinal uses
    Hot water extract of the bark is taken orally by the adult female as a tonic and emmenagogue. The hot water extract of the dried fixed oil is taken orally as an emmenagogue. Anthraquinone fraction of the dried flower, fruit and leaf is taken orally for leprosy. Hot water extract of the flower and leaf is taken orally as an antihistorical remedy, and is used externally to treat wounds. The dried flowers are taken orally for diabetes. Hot water extract of the dried fruit is used for piles and externally for skin diseases and ulcers. Hot water extract of the entire plant is taken orally as an anthelmintic, an insecticide and a purgative. Juices of the bark of Andrographis paniculate, Azadirachta indica and Tinospora cordifolia are taken orally as a treatment for filariasis. Hot water extract of the bark is taken with water, orally before breakfast, for leprosy. The extract is also taken for fever and diabetes, and as a tonic, refrigerant, anthelmintic and antiperiodic. The fresh fruit is used externally for leprosy. Fruit, leaf and root, ground and mixed with dried ginger and "trifala", a preparation consisting of the powdered fruit of Terminalia bellerica (Gaertn.) Roxb., T. Chebula Retz, and Emblica officinalis Gaertn., is taken orally with lukewarm water to treat common fevers. Leaf juice is administered by intravenous infusion for chronic skin diseases, and is taken orally as an anthelmintic. Source : Medicinal Plants of the World
S.No
Phytochemical Name
Phytochemical ID
Synonym
Part
2D structure
3D structure
1
Giganteol
N.A
Stem bark
2
α calotropeol
N.A
Stem bark
3
β calotropeol
N.A
Stem bark
4
β-amyrin
CID_73145
beta-Amyrenol Olean-12-en-3beta-ol
stem bark
5
Calotropnaphthalene
N.A
Root
6
calotropisesquiterpenol
N.A
Root
7
calotropisesterterpenol
N.A
Root
8
calotropbenzofuranone
N.A
9
palmitic acid
CID_985
Hexadecanoic acid
Seed
10
oleic acid
CID_445639
Cis-9-Octadecenoic acid oleate
Seed
11
linoleic and
CID_5280450
Linolic acid Telfairic acid
Seed
12
linolenic acid
CID_5280934
alpha-Linolenic acid linolenate
Seed
13
stigmasterol
CID_5280794
Stigmasterin
Seed
14
melissyl alcohol
CID_68972
Triacontanol Triacontan-1-ol Myricyl alcohol
Seed
15
laurane
N.A
Seed
16
holarrhetine
CID_50679144
N.A
Leaves
17
cyanidin-3-rhamnoglucoside
CID_29231
Keracyanin chloride KERACYANIN Antirrhinin Sambucin
Leaves
18
taraxasterol
CID_115250
Isolactucerol
Leaves
19
isovalerate
CID_3587356
isopropyl acetate 3-Methylbutyrate delphinate
Leaves
20
mudarine
N.A
Leaves
21
calotropin
CID_16142
Pecilocerin A
Leaves
22
uscharin
CID_11261800
Uscharine
Leaves
23
calotoxin
CID_30101
Leaves
24
caoutchouc
CID_6557
ISOPRENE 2-Methyl-1,3-butadiene
Latex
25
calotropains
N.A
Latex
26
α-amyrin
CID_73170
Viminalol
Latex

C. gigantea against HepG2 and MCF-7 cell lines with average IC50 values of 85.05 µg/ml and 92.4 µg/ml, respectively.

Source : Mushir et al.,2016

Disclaimer: The main motive behind the construction of this database is to compile information from the scientific literature on Indian medicinal plants to aid ongoing research efforts in the field of computational drug discovery.The curated data should be used only for research purposes and not for any self-diagnosis or any medical treatment.

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