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Centella asiatica 

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Common name : Indian Pennywort, coinwort, Indian water navelwort, pennyweed, Brahma Manduki
  • Vernacular Names
    1. Assamese : Mahaneem. Maha-neem 2. Bengali : Neem 3. English : Indian Lilac, Margosa, Margosa tree, Neem,Neem tree 4. Gujarati : Limba 5. Hindi : Neem 6. Irula : Veeppa, maram 7. Kannada : Bevu/ Kirubevu, Turakabevu 8. Malayalam : Ariyaveppu, Ayurveppu, Kaippanveppu , Nimbam, Vembu, Veppu 9. Marathi : Nimbay 10. Tamil : Sengumaru, Vembu, Veppa, Veppai 11. Telugu : Vepa Source : FRLHT’s ENVIS
  • Botanical Description
    Azadirachta indica is a tropical evergreen of the MELIACEAE family that grows up to 25 m high. It has rough dark brown bark with wide longitudinal fissures separated by flat ridges. The leaves are compound, imparipinnate, each comprising 5-15 leaflets that are arranged in alternate pairs with terminal leaflets. The compound leaves are themselves alternating with one another. The thin, lanceolate leaflets measure about 6 cm long and 2 cm broad. It bears many flowered panicles, mostly in the leaf-axils. The sepals are ovate and about 1 cm long with sweet scented white oblanceolate petals. It produces yellow drupes that are ellipsoid and glabrous, 12-20 cm long. Source : Medicinal plants of the world: chemical constituents, traditional and modem medicinal uses by Ivan Ross (Volume 2 )
  • Conservation Status
    Least concern source : IUCN
  • Medicinal uses
    Hot water extract of the bark is taken orally by the adult female as a tonic and emmenagogue. The hot water extract of the dried fixed oil is taken orally as an emmenagogue. Anthraquinone fraction of the dried flower, fruit and leaf is taken orally for leprosy. Hot water extract of the flower and leaf is taken orally as an antihistorical remedy, and is used externally to treat wounds. The dried flowers are taken orally for diabetes. Hot water extract of the dried fruit is used for piles and externally for skin diseases and ulcers. Hot water extract of the entire plant is taken orally as an anthelmintic, an insecticide and a purgative. Juices of the bark of Andrographis paniculate, Azadirachta indica and Tinospora cordifolia are taken orally as a treatment for filariasis. Hot water extract of the bark is taken with water, orally before breakfast, for leprosy. The extract is also taken for fever and diabetes, and as a tonic, refrigerant, anthelmintic and antiperiodic. The fresh fruit is used externally for leprosy. Fruit, leaf and root, ground and mixed with dried ginger and "trifala", a preparation consisting of the powdered fruit of Terminalia bellerica (Gaertn.) Roxb., T. Chebula Retz, and Emblica officinalis Gaertn., is taken orally with lukewarm water to treat common fevers. Leaf juice is administered by intravenous infusion for chronic skin diseases, and is taken orally as an anthelmintic. Source : Medicinal Plants of the World
S.No
Phytochemical Name
Phytochemical ID
Synonym
2D structure
3D structures
1
alpha-Humulene
CID_5281520
Humulene
2
Arjunolic acid
CID_73641
N.A
3
Asiatic acid
CID_119034
Dammarolic acid
4
Asiaticoside
CID_ 108062
Asiaticosid Emdecassol Madecassol
5
Asiaticoside B
CID_91618002
Terminoloside
6
Asiaticoside C
CID_101103169
N.A
7
Asiaticoside D
CID_102212084
N.A
8
Asiaticoside E
CID_102212085
N.A
9
Asiaticoside F
CID_53317001
N.A
10
Asiaticoside G
CID_53320941
N.A
11
β-Caryophyllene
CID_ 5281515
Caryophyllene
12
Bicyclogermacrene
CID_ 5315347
beta.-Cyclogermacrane
13
Brainoside B
CID_101504860
N.A
14
Campesterol
CID_173183
Campesterin
15
Castillicetin
CID_102394640
N.A
16
Castilliferol
CID_10526707
Kaempferol 3-p-coumarate
17
Catechin
CID_9064
N.A
18
Centellasapogenol A
CID_73196815
n.a
19
Centellasaponin A
CID_21633803
N.A
20
Centellasaponin B
CID_101140416
N.A
21
Centellasaponin C
CID_101103167
24
Centelloside D
CID_ 56964357
23
Centelloside E
CID_101568838
22
Centellasaponin D
CID_101103168
28
Corosolic acid
CID_6918774
Glucosol
27
Chlorogenic acid (3-O-Caffeoylquinic acid)
CID_ 1794427
26
Chebuloside II
CID_102005082
N.A
25
Chavicol
CID_68418
29
Cryptochlorogenic Acid, (4-O-Caffeoylquinic acid )
CID_9798666
4-Caffeoylquinic acid
32
3,4-Dicaffeoylquinic acid (Isochlorogenic acid B)
CID_5281780
N.A
31
1,5-Dicaffeoylquinic acid
CID_122685
N.A
30
1,3-Dicaffeoylquinic acid
CID_6474640
1,3-O-Dicaffeoylquinic acid
33
3,5-Dicaffeoylquinic acid (Isochlorogenic acid A)
CID_6474310
37
Eugenol acetate
CID_7136
Acetyleugenol
36
3-Epimaslinic acid
CID_ 25564831
35
Epicatechin
CID_ 72276
N.A
34
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C)
CID_6474309
N.A
38
Germacrene B
CID_5281519
N.A
39
Kaempferol
CID_5280863
Robigenin
40
Madecassic acid
CID_73412
brahmic acid
41
Madecassoside
CID_ 45356919
ASIATICOSIDE A
42
Methyleugenol
CID_7127
4-Allyl-1,2-dimethoxybenzene
43
Myrcene
CID_ 31253
Beta-myrcene
44
Myricetin
CID_5281672
Cannabiscetin Myricetol
45
Naringin
CID_442428
46
Neochlorogenic acid
CID_5280623
5-O-Caffeoylquinic acid Neochlorogenate Nochlorogenic acid
47
Patuletin
CID_5281678
6-Methoxyquercetin
48
Pomolic Acid
CID_382831
N.A
49
Ursolic acid
CID_64945
Prunol Malol Urson
50
Terminolic acid
CID_12314613
N.A
51
Stigmasterol
CID_ 5280794
Stigmasterin
52
Sitosterol
CID_222284
Sitosterol Cupreol Azuprostat
53
Scheffuroside F
CID_101675278
54
Scheffuroside B
CID_102212086
55
Rutin
CID_5280805
Rutoside Phytomelin Quercetin 3-rutinoside
56
Quercetin
CID_5280343
Meletin Sophoretin Quercetine
57
Quadranoside IV
CID_10372074
N.A

The AE showed elevated DPPH scavenging activity, with an IC(50) value of 31.25 microg/mL.

Source : Gray et al.,2019

Disclaimer: The main motive behind the construction of this database is to compile information from the scientific literature on Indian medicinal plants to aid ongoing research efforts in the field of computational drug discovery.The curated data should be used only for research purposes and not for any self-diagnosis or any medical treatment.

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