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Croton macrostachyus

Common name: Woodland croton, forest fever tree, broad-leaved croton
  • Vernacular Names
    1. Assamese : Mahaneem. Maha-neem 2. Bengali : Neem 3. English : Indian Lilac, Margosa, Margosa tree, Neem,Neem tree 4. Gujarati : Limba 5. Hindi : Neem 6. Irula : Veeppa, maram 7. Kannada : Bevu/ Kirubevu, Turakabevu 8. Malayalam : Ariyaveppu, Ayurveppu, Kaippanveppu , Nimbam, Vembu, Veppu 9. Marathi : Nimbay 10. Tamil : Sengumaru, Vembu, Veppa, Veppai 11. Telugu : Vepa Source : FRLHT’s ENVIS
  • Botanical Description
    Azadirachta indica is a tropical evergreen of the MELIACEAE family that grows up to 25 m high. It has rough dark brown bark with wide longitudinal fissures separated by flat ridges. The leaves are compound, imparipinnate, each comprising 5-15 leaflets that are arranged in alternate pairs with terminal leaflets. The compound leaves are themselves alternating with one another. The thin, lanceolate leaflets measure about 6 cm long and 2 cm broad. It bears many flowered panicles, mostly in the leaf-axils. The sepals are ovate and about 1 cm long with sweet scented white oblanceolate petals. It produces yellow drupes that are ellipsoid and glabrous, 12-20 cm long. Source : Medicinal plants of the world: chemical constituents, traditional and modem medicinal uses by Ivan Ross (Volume 2 )
  • Conservation Status
    Least concern source : IUCN
  • Medicinal uses
    Hot water extract of the bark is taken orally by the adult female as a tonic and emmenagogue. The hot water extract of the dried fixed oil is taken orally as an emmenagogue. Anthraquinone fraction of the dried flower, fruit and leaf is taken orally for leprosy. Hot water extract of the flower and leaf is taken orally as an antihistorical remedy, and is used externally to treat wounds. The dried flowers are taken orally for diabetes. Hot water extract of the dried fruit is used for piles and externally for skin diseases and ulcers. Hot water extract of the entire plant is taken orally as an anthelmintic, an insecticide and a purgative. Juices of the bark of Andrographis paniculate, Azadirachta indica and Tinospora cordifolia are taken orally as a treatment for filariasis. Hot water extract of the bark is taken with water, orally before breakfast, for leprosy. The extract is also taken for fever and diabetes, and as a tonic, refrigerant, anthelmintic and antiperiodic. The fresh fruit is used externally for leprosy. Fruit, leaf and root, ground and mixed with dried ginger and "trifala", a preparation consisting of the powdered fruit of Terminalia bellerica (Gaertn.) Roxb., T. Chebula Retz, and Emblica officinalis Gaertn., is taken orally with lukewarm water to treat common fevers. Leaf juice is administered by intravenous infusion for chronic skin diseases, and is taken orally as an anthelmintic. Source : Medicinal Plants of the World
S.No
Phytochemical Name
Phytochemical ID
Synonym
2D structure
3D structure
Part
1
Triterpene
N.A
Stem bark, twigs
2
Betulin
CID_72326
Betulinol Betuline Trochol
Stem bark, twig
3
Lupeol
CID_259846
Fagarasterol Clerodol Monogynol B
Stem bark, twigs
4
3𝛽-Acetoxy taraxer-14-en-28-oic acid
N.A
Roots
5
Lupenone
CID_92158
Lup-20(29)-en-3-one
Twigs
6
Betulinic acid
CID_64971
Betulic acid Mairin Lupatic Acid
Twigs
7
28-O-Acetylbetulin
CID_14038495
N.A
Twigs
8
Lupeol acetate
CID_92157
Lupeyl acetate 3-Acetyllupeol
Twigs
9
Zeorin
CID_159931
ZEORINE
Twigs
10
Crotepoxide
CID_161314
Futoxide
Fruits, stem bark, twigs
11
𝛽-Sitosterol
CID_222284
Sitosterol Cupreol Azuprostat
Stem bark, twigs
12
Stigmasterol
CID_5280794
Stigmasterin
Stem bark, twigs
13
𝛽-Sitosterol palmitate
CID_13747834
Sitosteryl palmitate
Twigs
14
Trachyloban-19-oic acid
CID_44560009
N.A
Roots
15
Trachyloban-18-oic acid
CID_101282656
N.A
Roots
16
Neoclerodan-5,10-en-19,6𝛽;20,12-diolide
N.A
Roots
17
3𝛼,19-Dihydroxytrachylobane
N.A
Roots
18
3𝛼,18,19-Trihydroxytrachylobane
N.A
Roots
19
Crotomacrine
N.A
Fruits
20
Floridolide A
CID_11370992
(8alpha,9S,10beta)-15,16-Epoxy-16-oxocleroda-3,13-dien-19-oic acid
Stem bark
21
Hardwickic acid
CID_161454
N.A
Stem bark
22
12-oxo-Hardwickic acid
N.A
Stem bark
23
Benzoic acid
CID_243
Dracylic acid benzenecarboxylic acid Carboxybenzene
Twigs
24
Methyl gallate
CID_7428
Methyl 3,4,5-trihydroxybenzoate
Twigs
25
Methyl 2,4-dihydroxy-3,6-dimethylbenzoate
CID_78435
methyl2,4-dihydroxy-3,6-dimethylbenzoate
Twigs
26
Lichexanthone
CID_5358904
1-Hydroxy-3,6-dimethoxy-8-methyl-9H-xanthen-9-one
Twigs

Among the tested extracts, the crude bark extract of Croton macrostachyus (AC) has the highest CC50 value of 45.9 ± 0.12 µg/mL followed by crude leaf extract of Croton megalocarpus (ELC) with a CC50 value of 27.7 ± 0.65 µg/mL.

Source : Alfred Maroyi,2017

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Disclaimer: The main motive behind the construction of this database is to compile information from the scientific literature on Indian medicinal plants to aid ongoing research efforts in the field of computational drug discovery.The curated data should be used only for research purposes and not for any self-diagnosis or any medical treatment.

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