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Garcinia polyantha 

  • Vernacular Names
    1. Assamese : Mahaneem. Maha-neem 2. Bengali : Neem 3. English : Indian Lilac, Margosa, Margosa tree, Neem,Neem tree 4. Gujarati : Limba 5. Hindi : Neem 6. Irula : Veeppa, maram 7. Kannada : Bevu/ Kirubevu, Turakabevu 8. Malayalam : Ariyaveppu, Ayurveppu, Kaippanveppu , Nimbam, Vembu, Veppu 9. Marathi : Nimbay 10. Tamil : Sengumaru, Vembu, Veppa, Veppai 11. Telugu : Vepa Source : FRLHT’s ENVIS
  • Botanical Description
    Azadirachta indica is a tropical evergreen of the MELIACEAE family that grows up to 25 m high. It has rough dark brown bark with wide longitudinal fissures separated by flat ridges. The leaves are compound, imparipinnate, each comprising 5-15 leaflets that are arranged in alternate pairs with terminal leaflets. The compound leaves are themselves alternating with one another. The thin, lanceolate leaflets measure about 6 cm long and 2 cm broad. It bears many flowered panicles, mostly in the leaf-axils. The sepals are ovate and about 1 cm long with sweet scented white oblanceolate petals. It produces yellow drupes that are ellipsoid and glabrous, 12-20 cm long. Source : Medicinal plants of the world: chemical constituents, traditional and modem medicinal uses by Ivan Ross (Volume 2 )
  • Conservation Status
    Least concern source : IUCN
  • Medicinal uses
    Hot water extract of the bark is taken orally by the adult female as a tonic and emmenagogue. The hot water extract of the dried fixed oil is taken orally as an emmenagogue. Anthraquinone fraction of the dried flower, fruit and leaf is taken orally for leprosy. Hot water extract of the flower and leaf is taken orally as an antihistorical remedy, and is used externally to treat wounds. The dried flowers are taken orally for diabetes. Hot water extract of the dried fruit is used for piles and externally for skin diseases and ulcers. Hot water extract of the entire plant is taken orally as an anthelmintic, an insecticide and a purgative. Juices of the bark of Andrographis paniculate, Azadirachta indica and Tinospora cordifolia are taken orally as a treatment for filariasis. Hot water extract of the bark is taken with water, orally before breakfast, for leprosy. The extract is also taken for fever and diabetes, and as a tonic, refrigerant, anthelmintic and antiperiodic. The fresh fruit is used externally for leprosy. Fruit, leaf and root, ground and mixed with dried ginger and "trifala", a preparation consisting of the powdered fruit of Terminalia bellerica (Gaertn.) Roxb., T. Chebula Retz, and Emblica officinalis Gaertn., is taken orally with lukewarm water to treat common fevers. Leaf juice is administered by intravenous infusion for chronic skin diseases, and is taken orally as an anthelmintic. Source : Medicinal Plants of the World
Phytochemical Name
Phytochemical ID
Synonym
Part
2D structure
3D structure
Medicinal uses
1,3,5,6 Tetrahydroxyxanthone
CID_5479774
1,3,5,6-TETRAHYDROXY-9H-XANTHEN-9-ONE
Wood trunk
Antimalarial
1,6-dihydroxy-5-methoxyxanthone
CID_5481840
Buchanaxanthone
Wood trunk
Antimalarial
1,5-dihydroxyxanthone
CID_5480299
1,5-dihydroxyxanthen-9-one
Wood trunk
Antimalarial
1,3,5-trihydroxyxanthone
CID_5281663
1,3,5-trihydroxy-9H-xanthen-9-one
Wood trunk
Antimalarial
Polyanxanthone C
CID_101844608
N.A
Wood trunk
Antimalarial
Polyanxanthone B
CID_24814165
N.A
Wood trunk
Antimalarial
Polyanxanthone A
CID_24814164
N.A
Wood trunk
Antimalarial
b-sitosterol
CID_222284
Sitosterol Cupreol Azuprostat
Root bark
Antimalarial
Magnificol
CID_44575983
N.A
Root bark
Antimalarial
Isoxanthochymol
CID_10461245
N.A
Root bark
Antimalarial
Chefouxanthone
N.A
Root bark
Antimalarial
Smeathxanthone B
CID_11625362
N.A
Root bark
Antimalarial
Smeathxanthone A
CID_11509473
2-[(2E)-3,7-dimethylocta-2,6-dienyl]-1,3,5,8-tetrahydroxy-xanthen-9-one
Root bark
Antimalarial
Garcinane
CID_25105257
N.A
Root bark
Antimalarial
Garciniaxanthone I
N.A
Root bark
Antimalarial
2-hydroxy-1,7-dimethoxyxanthone
CID_12133312
N.A
Stem bark
Antioxidant
1,5-dihydroxyxanthone
CID_5480299
1,5-dihydroxyxanthen-9-one
Stem bark
Antioxidant
Lupeol
CID_259846
Fagarasterol Clerodol Monogynol B
Stem bark
Antioxidant
Oleanolic acid
CID_10494
Oleanic acid Caryophyllin Astrantiagenin C
Stem bark
Antioxidant
Friedelin
CID_91472
Friedeline
Stem bark
Antioxidant
Bangangxanthone B
CID_11536905
N.A
Stem bark
Antioxidant
Bangangxanthone A
CID_11524043
N.A
Stem bark
Antioxidant

Isoxanthochymol (2) and 4-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one (3) exhibited significant antiproliferative activity against the leukemia cell line TPH-1 with IC50 inhibition values of 1.5 and 2.8 μg/ml, respectively.

Source: Hemshekhar et al.,2011

Disclaimer: The main motive behind the construction of this database is to compile information from the scientific literature on Indian medicinal plants to aid ongoing research efforts in the field of computational drug discovery.The curated data should be used only for research purposes and not for any self-diagnosis or any medical treatment.

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