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Holarrhena antidysenterica 

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Common name :  Kurchi, Kawar, Kura
  • Vernacular Names
    1. Assamese : Mahaneem. Maha-neem 2. Bengali : Neem 3. English : Indian Lilac, Margosa, Margosa tree, Neem,Neem tree 4. Gujarati : Limba 5. Hindi : Neem 6. Irula : Veeppa, maram 7. Kannada : Bevu/ Kirubevu, Turakabevu 8. Malayalam : Ariyaveppu, Ayurveppu, Kaippanveppu , Nimbam, Vembu, Veppu 9. Marathi : Nimbay 10. Tamil : Sengumaru, Vembu, Veppa, Veppai 11. Telugu : Vepa Source : FRLHT’s ENVIS
  • Botanical Description
    Azadirachta indica is a tropical evergreen of the MELIACEAE family that grows up to 25 m high. It has rough dark brown bark with wide longitudinal fissures separated by flat ridges. The leaves are compound, imparipinnate, each comprising 5-15 leaflets that are arranged in alternate pairs with terminal leaflets. The compound leaves are themselves alternating with one another. The thin, lanceolate leaflets measure about 6 cm long and 2 cm broad. It bears many flowered panicles, mostly in the leaf-axils. The sepals are ovate and about 1 cm long with sweet scented white oblanceolate petals. It produces yellow drupes that are ellipsoid and glabrous, 12-20 cm long. Source : Medicinal plants of the world: chemical constituents, traditional and modem medicinal uses by Ivan Ross (Volume 2 )
  • Conservation Status
    Least concern source : IUCN
  • Medicinal uses
    Hot water extract of the bark is taken orally by the adult female as a tonic and emmenagogue. The hot water extract of the dried fixed oil is taken orally as an emmenagogue. Anthraquinone fraction of the dried flower, fruit and leaf is taken orally for leprosy. Hot water extract of the flower and leaf is taken orally as an antihistorical remedy, and is used externally to treat wounds. The dried flowers are taken orally for diabetes. Hot water extract of the dried fruit is used for piles and externally for skin diseases and ulcers. Hot water extract of the entire plant is taken orally as an anthelmintic, an insecticide and a purgative. Juices of the bark of Andrographis paniculate, Azadirachta indica and Tinospora cordifolia are taken orally as a treatment for filariasis. Hot water extract of the bark is taken with water, orally before breakfast, for leprosy. The extract is also taken for fever and diabetes, and as a tonic, refrigerant, anthelmintic and antiperiodic. The fresh fruit is used externally for leprosy. Fruit, leaf and root, ground and mixed with dried ginger and "trifala", a preparation consisting of the powdered fruit of Terminalia bellerica (Gaertn.) Roxb., T. Chebula Retz, and Emblica officinalis Gaertn., is taken orally with lukewarm water to treat common fevers. Leaf juice is administered by intravenous infusion for chronic skin diseases, and is taken orally as an anthelmintic. Source : Medicinal Plants of the World
S.No
Phytochemical Name
Phytochemical ID
Synonyms
Part
2D structure
3D structure
1
Conarrhimine
CID_12303820
N.A
Stem bark and seeds
2
Conessimine/Isoconessimine
CID_12303831
N.A
Stem bark and seeds
3
Conessine
CID_441082
Roquessine Neriine Conessinum
Stem bark and seeds
4
Isoconessine
CID_202033
N.A
Stem bark and seeds
5
holadysenterine
CID_16742955
N.A
Stem bark and seeds
6
(20)-N-Methylholarrhimine
N.A
Stem bark
7
(3)-N-Methylholarrhimine
N.A
Stem bark
8
3a-Aminoconan-5-ene
N.A
Stem bark
9
7α-Hydroxyconessine
N.A
Stem bark
10
Conamine
CID_50543761
Stem bark
11
Conessidine
CID_22214027
N.A
Stem bark
12
Conkurchine
N.A
Stem bark
13
Conkurchine
N.A
Stem bark
14
Di-hydro-isoconessimine
N.A
Stem bark
15
Holacetine
N.A
Stem bark
16
Holacine
N.A
Stem bark
17
Holadiene
N.A
Stem bark
18
Holadysenterine
CID_16742955
N.A
Stem bark
19
Holadysone
CID_101306734
N.A
Stem bark
20
Holafrine
CID_51142156
Stem bark
21
Holarrhenine
CID_12310556
N.A
Stem bark
22
Holarrhessimine
N.A
Stem bark
23
Holarrhidine
N.A
Stem bark
24
Holarrhimine/Kurchicine
CID_15559632
Golarrimin Holarrimin
Stem bark
25
Holarrhine
N.A
Stem bark
26
Holarrifine
N.A
Stem bark
27
Holonamine
CID_76308534
N.A
Stem bark
28
Kurchamide
N.A
Stem bark
30
Kurchenine
N.A
Stem bark
29
Kurchamine
CID_15560372
Kurchamin
Stem bark
31
Kurchessine
CID_442979
Irehdiamine I
Stem bark
32
Kurchilidine
N.A
Stem bark
33
Kurchimine
N.A
Stem bark
34
Kurchinidine
N.A
Stem bark
35
Kurchinine
N.A
Stem bark
37
Lettocine
N. A
Stem bark
38
Neoconessine
N.A
Stem bark
39
NNN’N’-Tetramethylholarrhimine
N.A
Stem bark
40
Norholadiene
CID_101672255
N.A
Stem bark
36
Kurcholessine
CID_20054951
N.A
Stem bark
41
Pubadysone
CID_12044303
N.A
Stem bark
42
Pubamide
CID_12044304
N.A
Stem bark
43
Pubescimine
CID_101672378
N.A
Stem bark
44
Pubescine
CID_72313
Raubasinine Raubasinin
Stem bark
45
Puboestrene
CID_92846
estrone acetate
Stem bark
46
Regholarrhenine A
N.A
Stem bark
47
Regholarrhenine B
N.A
Stem bark
48
Regholarrhenine B
N.A
Stem bark
49
Regholarrhenine D
CID_101529337
N.A
Stem bark
50
Regholarrhenine E
CID_101529338
N.A
Stem bark
51
Regholarrhenine F
CID_14543701
N.A
Stem bark
52
Trimethylconkurchine
N.A
Stem bark
53
Holarosine A
CID_101306835
N.A
Leaves
54
Holarosine B
N.A
Leaves
55
Holarricine
N.A
Leaves
56
Holantosine-A
CID_101967079
Leaves
57
Holantosine-B
CID_12310550
N. A
Leaves
58
Holantosine-C
CID_101306836
N.A
Leaves
59
Holantosine-D
CID_101316776
Leaves
60
Holantosine-E
N.A
Leaves
61
Holantosine-F
N.A
Leaves
62
Kurchiphyllamine
CID_52584925
Leaves
63
Kurchaline
CID_102093814
Leaves
64
Kurchiphylline
CID_52853965
Leaves
65
Antidysentericine
CID_132918182
Seeds
66
Conimine
CID_101686
Seeds

The IC50 values of bark and leaf of H. antidysenterica were 10.15 and 8.56 µg/ml respectively on DPPH scavenging assay.

Source : Gopinath et al 2019

Disclaimer: The main motive behind the construction of this database is to compile information from the scientific literature on Indian medicinal plants to aid ongoing research efforts in the field of computational drug discovery.The curated data should be used only for research purposes and not for any self-diagnosis or any medical treatment.

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